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The mechanism of rate-limiting motions in enzyme function
The ability to use conformational flexibility is a hallmark of enzyme function. Here we show that protein motions and catalytic activity in a RNase are coupled and display identical solvent isotope effects. Solution NMR relaxation experiments identify a cluster of residues, some distant from the act...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1924554/ https://ncbi.nlm.nih.gov/pubmed/17615241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702551104 |
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