Absence of donor T-cell–derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity

Tumor necrosis factor (TNF) plays an important role in graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) activity after allogeneic bone marrow transplantation (allo-BMT). TNF can be expressed in a membrane-bound form (memTNF) and as a soluble (solTNF) molecule after being cleaved by the...

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Main Authors: Borsotti, Chiara, Franklin, Anna R. K., Lu, Sydney X., Kim, Theo D., Smith, Odette M., Suh, David, King, Chris G., Chow, Andrew, Liu, Chen, Alpdogan, Onder, van den Brink, Marcel R. M.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2007
Teme:
Transplantation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924485/
https://ncbi.nlm.nih.gov/pubmed/17395784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-10-054510
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