Development of halofantrine resistance and determination of cross-resistance patterns in Plasmodium falciparum.

Intermittent exposure to halofantrine (HF) of both chloroquine-susceptible (T9.96) and chloroquine-resistant (K1) isolates of Plasmodium falciparum in vitro resulted in a rapid reduction in susceptibility to HF. After 6 months, the 50% inhibitory concentration (IC50) of HF, determined with [G-3H]hyp...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Nateghpour, M, Ward, S A, Howells, R E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192389/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8285616/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.11.2337
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