From oligonucleotide shapes to genomic SELEX: Novel biological regulatory loops

The SELEX method and oligonucleotide combinatorial chemistry discovery process yields high-affinity/high-specificity ligands for virtually any molecular target. Typically, the enormous starting libraries used in the SELEX process contain 10(14)–10(15) sequences. We now ask if the smaller sequences,...

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Hlavní autoři: Gold, Larry, Brown, David, He, Yi-yuan, Shtatland, Timur, Singer, Britta S., Wu, Yan
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences of the USA 1997
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC19236/
https://ncbi.nlm.nih.gov/pubmed/8990161
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