Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity.

The NS5B protein of the hepatitis C virus (HCV) is an RNA-dependent RNA polymerase (RdRp) (S.-E. Behrens, L. Tomei, and R. De Francesco, EMBO J. 15:12-22, 1996) that is assumed to be required for replication of the viral genome. To further study the biochemical and structural properties of this enzy...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Lohmann, V, Körner, F, Herian, U, Bartenschlager, R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192304/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9343198/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.11.8416-8428.1997
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