Discrepancies in bioassay and chromatography determinations explained by metabolism of itraconazole to hydroxyitraconazole: studies of interpatient variations in concentrations.

Pharmacologic studies of itraconazole (IZ), a triazole antifungal, indicated unexplained differences between bioassay and chromatographic determinations and large variations in steady-state blood concentrations. We show that concentrations of a hydroxylated metabolite, hydroxyitraconazole (HIZ), are...

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Detaylı Bibliyografya

Yayımlandı:	Antimicrob Agents Chemother
Asıl Yazarlar:	Hostetler, J S, Heykants, J, Clemons, K V, Woestenborghs, R, Hanson, L H, Stevens, D A
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	American Society for Microbiology (ASM) 1993
Konular:	Research Article
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192254/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8257148/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.10.2224
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