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Influence of Gender, Body Mass Index, and Age on the Pharmacokinetics of Itraconazole in Healthy Subjects: Non-Compartmental Versus Compartmental Analysis

Itraconazole is a triazole antifungal agent with highly variable pharmacokinetics, with not yet fully identified factors as the source of this variability. Our study aimed to examine the influence of body mass index, gender, and age on the first dose pharmacokinetics of itraconazole in healthy subje...

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Principais autores: Milijana N. Miljković, Nemanja Rančić, Aleksandra Kovačević, Bojana Cikota-Aleksić, Ivan Skadrić, Vesna Jaćević, Momir Mikov, Viktorija Dragojević-Simić
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-06-01
coleção:Frontiers in Pharmacology
Assuntos:
itraconazole
hydroxy-itraconazole
gender
non-compartmental analysis
compartmental analysis
genetic polymorphism
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2022.796336/full
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