CGP 53437, an orally bioavailable inhibitor of human immunodeficiency virus type 1 protease with potent antiviral activity.

CGP 53437 is a peptidomimetic inhibitor of human immunodeficiency virus type 1 (HIV-1) protease containing a hydroxyethylene isostere. The compound inhibited recombinant HIV-1 protease with a Ki of 0.2 nM. The inhibition constant versus human cathepsin D and human cathepsin E was 4 nM. Human pepsin...

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Publicat a:	Antimicrob Agents Chemother
Autors principals:	Alteri, E, Bold, G, Cozens, R, Faessler, A, Klimkait, T, Lang, M, Lazdins, J, Poncioni, B, Roesel, J L, Schneider, P
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 1993
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192233/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8257128/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.10.2087
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