CGP 53437, an orally bioavailable inhibitor of human immunodeficiency virus type 1 protease with potent antiviral activity.

CGP 53437 is a peptidomimetic inhibitor of human immunodeficiency virus type 1 (HIV-1) protease containing a hydroxyethylene isostere. The compound inhibited recombinant HIV-1 protease with a Ki of 0.2 nM. The inhibition constant versus human cathepsin D and human cathepsin E was 4 nM. Human pepsin...

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Hauptverfasser: Alteri, E, Bold, G, Cozens, R, Faessler, A, Klimkait, T, Lang, M, Lazdins, J, Poncioni, B, Roesel, J L, Schneider, P
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1993
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC192233/
https://ncbi.nlm.nih.gov/pubmed/8257128
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