Piperacillin, tazobactam, and gentamicin alone or combined in an endocarditis model of infection by a TEM-3-producing strain of Klebsiella pneumoniae or its susceptible variant.

The efficacy of tazobactam, a beta-lactamase inhibitor, in combination with piperacillin, was studied in vitro and in rabbit experimental endocarditis due to a Klebsiella pneumoniae strain (KpR) producing an extended-spectrum beta-lactamase, TEM-3, or its nonproducing variant (KpS). In vitro, pipera...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Mentec, H, Vallois, J M, Bure, A, Saleh-Mghir, A, Jehl, F, Carbon, C
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192204/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1329634/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.9.1883
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