Evolution of the Sabin type 1 poliovirus in humans: characterization of strains isolated from patients with vaccine-associated paralytic poliomyelitis.

Attenuated strains of the Sabin oral poliovirus vaccine replicate in the human gut and in rare cases cause vaccine-associated paralytic poliomyelitis (VAPP). Reversion of vaccine strains toward a pathogenic phenotype is probably one of the main causes of VAPP, a disease most frequently associated wi...

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Autors principals: Georgescu, M M, Balanant, J, Macadam, A, Otelea, D, Combiescu, M, Combiescu, A A, Crainic, R, Delpeyroux, F
Format: Artigo
Idioma:Inglês
Publicat: 1997
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC192128/
https://ncbi.nlm.nih.gov/pubmed/9311861
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