Moloney murine leukemia virus-derived retroviral vectors decay intracellularly with a half-life in the range of 5.5 to 7.5 hours.

Replication-incompetent recombinant retroviruses are currently used for gene delivery. The limited efficiency of gene transfer using these vectors hampers implementation of gene therapy. Successful integration of Moloney murine leukemia virus (MMuLV)-derived retroviral vectors into the host cell DNA...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Andreadis, S T, Brott, D, Fuller, A O, Palsson, B O
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192101/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9311834/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.10.7541-7548.1997
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