Decreased cyclin B1 expression contributes to G2 delay in human brain tumor cells after treatment with camptothecin.

DNA damage produces delayed mitosis (G2/M delay) in proliferating cells, and shortening the delay sensitizes human malignant glioma and medulloblastoma cells to cytotoxic chemotherapy. Although activation of the cyclin-dependent kinase CDC2 mediates G2/M transition in all tumor cells studied to date...

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Detalhes bibliográficos
Main Authors: Janss, A. J., Maity, A., Tang, C. B., Muschel, R. J., McKenna, W. G., Sutton, L., Phillips, P. C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1920603/
https://ncbi.nlm.nih.gov/pubmed/11305412
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