Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection

BACKGROUND: CD4+ T cell help is critical in maintaining antiviral immune responses and such help has been shown to be sustained in acute resolving hepatitis C. In contrast, in evolving chronic hepatitis C CD4+ T cell helper responses appear to be absent or short-lived, using functional assays. METHO...

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Main Authors: Lucas, Michaela, Ulsenheimer, Axel, Pfafferot, Katja, Heeg, Malte H.J., Gaudieri, Silvana, Grüner, Norbert, Rauch, Andri, Gerlach, J. Tilman, Jung, Maria-Christina, Zachoval, Reinhart, Pape, Gerd R., Schraut, Winfried, Santantonio, Teresa, Nitschko, Hans, Obermeier, Martin, Phillips, Rodney, Scriba, Thomas J., Semmo, Nasser, Day, Cheryl, Weber, Jonathan N., Fidler, Sarah, Thimme, Robert, Haberstroh, Anita, Baumert, Thomas F., Klenerman, Paul, Diepolder, Helmut M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1920556/
https://ncbi.nlm.nih.gov/pubmed/17653276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000649
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