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Ex vivo nerve growth factor gene transfer to the basal forebrain in presymptomatic middle-aged rats prevents the development of cholinergic neuron atrophy and cognitive impairment during aging

Nerve growth factor (NGF) is able to restore spatial learning and reverse forebrain cholinergic neuron atrophy when administered intracerebrally to behaviorally impaired aged rats. In the present study, behaviorally unimpaired, middle-aged rats (14–16 months old) received transplants of ex vivo tran...

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Autors principals: Martínez-Serrano, Alberto, Björklund, Anders
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC19203/
https://ncbi.nlm.nih.gov/pubmed/9465107
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