The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3′ processing and transcription termination

Termination of RNA polymerase II transcription frequently requires a poly(A) signal and cleavage/polyadenylation factors. Recent work has shown that degradation of the downstream cleaved RNA by the exonuclease XRN2 promotes termination, but how XRN2 functions with 3′-processing factors to elicit ter...

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Bibliographic Details
Main Authors: Kaneko, Syuzo, Rozenblatt-Rosen, Orit, Meyerson, Matthew, Manley, James L.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2007
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1920172/
https://ncbi.nlm.nih.gov/pubmed/17639083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1565207
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