Immunization with plasmid DNA encoding hepatitis C virus envelope E2 antigenic domains induces antibodies whose immune reactivity is linked to the injection mode.

Plasmids expressing different domains of the hepatis C virus (HCV) envelope E2 glycoprotein from a genotype 1a isolate were constructed to compare the immunogenic potential of E2 in nucleic acid-based immunizations. One plasmid, pCIE2t, expressed a C-terminally truncated form of E2, while others, pS...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Nakano, I, Maertens, G, Major, M E, Vitvitski, L, Dubuisson, J, Fournillier, A, De Martynoff, G, Trepo, C, Inchauspe, G
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192006/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9261444/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.9.7101-7109.1997
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