Induction of Hepatitis C Virus E1 Envelope Protein-Specific Immune Response Can Be Enhanced by Mutation of N-Glycosylation Sites

Deglycosylation of viral glycoproteins has been shown to influence the number of available epitopes and to modulate immune recognition of antigens. We investigated the role played by N-glycans in the immunogenicity of hepatitis C virus (HCV) E1 envelope glycoprotein, a naturally poor immunogen. Eigh...

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Detalhes bibliográficos
Main Authors: Fournillier, A., Wychowski, C., Boucreux, D., Baumert, T. F., Meunier, J.-C., Jacobs, D., Muguet, S., Depla, E., Inchauspé, G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC116104/
https://ncbi.nlm.nih.gov/pubmed/11711599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.24.12088-12097.2001
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