Phosphorylation in the serine/threonine 2609–2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts

Previous work suggested that phosphorylation of DNA-PKcs at several serine/threonine (S/T) residues at positions 2609–2647 promotes DNA-PK-dependent end joining. In an attempt to clarify the role of such phosphorylation, end joining was examined in extracts of DNA-PKcs-deficient M059J cells. Joining...

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Hlavní autoři: Povirk, Lawrence F., Zhou, Rui-Zhe, Ramsden, Dale A., Lees-Miller, Susan P., Valerie, Kristoffer
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2007
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1919499/
https://ncbi.nlm.nih.gov/pubmed/17526517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm339
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