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Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites.

Two different responses to the therapy were observed in a group of patients receiving the protease inhibitor indinavir. In one, suppression of virus replication occurred and has persisted for 90 weeks (bDNA, < 500 human immunodeficiency virus type 1 [HIV-1] RNA copies/ml). In the second group, a reb...

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Udgivet i:J Virol
Principais autores: Zhang, Y M, Imamichi, H, Imamichi, T, Lane, H C, Falloon, J, Vasudevachari, M B, Salzman, N P
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191944/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9261388/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.9.6662-6670.1997
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