Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites.

Two different responses to the therapy were observed in a group of patients receiving the protease inhibitor indinavir. In one, suppression of virus replication occurred and has persisted for 90 weeks (bDNA, < 500 human immunodeficiency virus type 1 [HIV-1] RNA copies/ml). In the second group, a...

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Hlavní autoři: Zhang, Y M, Imamichi, H, Imamichi, T, Lane, H C, Falloon, J, Vasudevachari, M B, Salzman, N P
Médium: Artigo
Jazyk:Inglês
Vydáno: 1997
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC191944/
https://ncbi.nlm.nih.gov/pubmed/9261388
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