Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites.

Documenti analoghi

• Emergence of protease inhibitor resistance mutations in human immunodeficiency virus type 1 isolates from patients and rapid screening procedure for their detection.
  di: Vasudevachari, M B, et al.
  Pubblicazione: (1996)
• Human Immunodeficiency Virus Type 1 Protease Cleavage Site Mutations Associated with Protease Inhibitor Cross-Resistance Selected by Indinavir, Ritonavir, and/or Saquinavir
  di: Côté, Hélène C. F., et al.
  Pubblicazione: (2001)
• Functional Correlation between a Novel Amino Acid Insertion at Codon 19 in the Protease of Human Immunodeficiency Virus Type 1 and Polymorphism in the p1/p6 Gag Cleavage Site in Drug Resistance and Replication Fitness
  di: Brann, Terrence W., et al.
  Pubblicazione: (2006)
• Mutagenesis of protease cleavage sites in the human immunodeficiency virus type 1 gag polyprotein.
  di: Tritch, R J, et al.
  Pubblicazione: (1991)
• Analysis of cleavage site mutations between the NC and PR Gag domains of Rous sarcoma virus.
  di: Schatz, G, et al.
  Pubblicazione: (1997)