Novel Peptide Sequence (“IQ-tag”) with High Affinity for NIR Fluorochromes Allows Protein and Cell Specific Labeling for In Vivo Imaging

BACKGROUND: Probes that allow site-specific protein labeling have become critical tools for visualizing biological processes. METHODS: Here we used phage display to identify a novel peptide sequence with nanomolar affinity for near infrared (NIR) (benz)indolium fluorochromes. The developed peptide s...

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Bibliographic Details
Main Authors: Kelly, Kimberly A., Carson, Jonathan, McCarthy, Jason R., Weissleder, Ralph
Format: Artigo
Language:Inglês
Published: Public Library of Science 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1919420/
https://ncbi.nlm.nih.gov/pubmed/17653285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000665
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