Both conserved region 1 (CR1) and CR2 of the human papillomavirus type 16 E7 oncogene are required for induction of epidermal hyperplasia and tumor formation in transgenic mice.

High-risk human papillomavirus type 16 (HPV-16) and HPV-18 are associated with the majority of human cervical carcinomas, and two viral genes, HPV E6 and E7, are commonly found to be expressed in these cancers. The presence of HPV-16 E7 is sufficient to induce epidermal hyperplasia and epithelial tu...

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Pubblicato in:	J Virol
Autori principali:	Gulliver, G A, Herber, R L, Liem, A, Lambert, P F
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191846/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9223480/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.8.5905-5914.1997
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