The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein.

Documenti analoghi

• Addition of a Missense Mutation Present in the L Gene of Respiratory Syncytial Virus (RSV) cpts530/1030 to RSV Vaccine Candidate cpts248/404 Increases Its Attenuation and Temperature Sensitivity
  di: Whitehead, Stephen S., et al.
  Pubblicazione: (1999)
• The Major Attenuating Mutations of the Respiratory Syncytial Virus Vaccine Candidate cpts530/1009 Specify Temperature-Sensitive Defects in Transcription and Replication and a Non-Temperature-Sensitive Alteration in mRNA Termination
  di: Juhasz, Katalin, et al.
  Pubblicazione: (1999)
• Recombinant Respiratory Syncytial Virus (RSV) Bearing a Set of Mutations from Cold-Passaged RSV Is Attenuated in Chimpanzees
  di: Whitehead, Stephen S., et al.
  Pubblicazione: (1998)
• Identification of Mutations Contributing to the Temperature-Sensitive, Cold-Adapted, and Attenuation Phenotypes of the Live-Attenuated Cold-Passage 45 (cp45) Human Parainfluenza Virus 3 Candidate Vaccine
  di: Skiadopoulos, Mario H., et al.
  Pubblicazione: (1999)
• Respiratory syncytial virus ts mutants and nuclear immunofluorescence.
  di: Faulkner, G P, et al.
  Pubblicazione: (1976)