The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein.

cpts530, a candidate live-virus vaccine, is an attenuated strain of human respiratory syncytial virus (RSV). It was derived by subjecting a cold-passaged (cp) strain of RSV to a single round of chemical mutagenesis. cpts530 is a temperature-sensitive (ts) mutant that is attenuated in mice and chimpa...

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Библиографические подробности

Опубликовано в::	J Virol
Главные авторы:	Juhasz, K, Whitehead, S S, Bui, P T, Biggs, J M, Crowe, J E, Boulanger, C A, Collins, P L, Murphy, B R
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 1997
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191836/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9223470/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.8.5814-5819.1997
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