Subunit-specific mutagenesis of the cysteine 280 residue of the reverse transcriptase of human immunodeficiency virus type 1: effects on sensitivity to a specific inhibitor of the RNase H activity.

Treatment of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) with N-ethylmaleimide (NEM) selectively inhibits the RNase H activity. The cysteine residue at position 280 (C280) is the target for NEM; HIV-1 RT carrying the mutation C280S is resistant to NEM. Since HIV-1 RT is comp...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Loya, S, Gao, H Q, Avidan, O, Boyer, P L, Hughes, S H, Hizi, A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191814/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9188646/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.7.5668-5672.1997
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