Increase in the frequency of hepadnavirus DNA integrations by oxidative DNA damage and inhibition of DNA repair.

Persistent hepadnavirus infection leads to oxidative stress and DNA damage through increased production of toxic oxygen radicals. In addition, hepadnaviral DNA integrations into chromosomal DNA can promote the process of hepatocarcinogenesis (M. Feitelson, Clin. Microbiol. Rev. 5:275-301, 1992). Whi...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Petersen, J, Dandri, M, Bürkle, A, Zhang, L, Rogler, C E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9188618/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.7.5455-5463.1997
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