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Increase in the frequency of hepadnavirus DNA integrations by oxidative DNA damage and inhibition of DNA repair.

Persistent hepadnavirus infection leads to oxidative stress and DNA damage through increased production of toxic oxygen radicals. In addition, hepadnaviral DNA integrations into chromosomal DNA can promote the process of hepatocarcinogenesis (M. Feitelson, Clin. Microbiol. Rev. 5:275-301, 1992). Whi...

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Bibliografiske detaljer
Udgivet i:J Virol
Principais autores: Petersen, J, Dandri, M, Bürkle, A, Zhang, L, Rogler, C E
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1997
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191786/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9188618/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.7.5455-5463.1997
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