Pharmacological properties of FPL 63547, a novel inhibitor of angiotensin-converting enzyme.

1. FPL 63547, in its active diacid form, was a potent inhibitor of rabbit lung angiotension converting enzyme (ACE) in vitro (IC50 0.51 nM). 2. In conscious normotensive dogs, FPL 63547 (10-300 micrograms kg-1 i.v.) produced prolonged, dose-related inhibition of plasma ACE activity and angiotensin I...

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Autori principali: Carr, R. D., Higgs, L., Killingback, P. G., Nicol, A. K., O'Connor, S. E., Robson, A., Wells, E., Simpson, W. T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1990
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1917465/
https://ncbi.nlm.nih.gov/pubmed/2164863
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