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Desensitization of prostacyclin responsiveness in a neuronal hybrid cell line: selective loss of high affinity receptors.

The binding of [3H]-iloprost (ZK36374) to NCB-20 membranes revealed a single population of high affinity receptors (KD = 9.55 nM, Bmax = 431 fmol mg-1 protein) and a low affinity, non-saturable binding component. Desensitization of prostacyclin-responsiveness of NCB-20 cells is induced by culture in...

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Autori principali: Leigh, P. J., MacDermot, J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1985
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1916758/
https://ncbi.nlm.nih.gov/pubmed/2992650
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