dUTPase-minus caprine arthritis-encephalitis virus is attenuated for pathogenesis and accumulates G-to-A substitutions.

The importance of the virally encoded dUTPase for CAEV replication, invasiveness, pathogenesis, and genetic stability was investigated in goats infected by viruses with single point (DU-G) and deletion (DU-1) mutations of the dUTPase gene (DU gene). The DU gene was found to be dispensable for CAEV r...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Turelli, P, Guiguen, F, Mornex, J F, Vigne, R, Quérat, G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191673/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9151845/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.6.4522-4530.1997
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