The Rep78 gene product of adeno-associated virus (AAV) self-associates to form a hexameric complex in the presence of AAV ori sequences.

The Rep78 and Rep68 proteins of adeno-associated virus (AAV) are replication initiator proteins that bind the viral replicative-form origin of replication, nick the origin in a site- and strand-specific fashion, and mediate vectorial unwinding of the DNA duplex via an ATP-dependent helicase activity...

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Detalles Bibliográficos

Publicado en:	J Virol
Autores principales:	Smith, R H, Spano, A J, Kotin, R M
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1997
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191665/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9151837/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.6.4461-4471.1997
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