Conservation and host specificity of Vpr-mediated cell cycle arrest suggest a fundamental role in primate lentivirus evolution and biology.

The human immunodeficiency virus type 1 (HIV-1) Vpr protein prevents infected cells from passing through mitosis by arresting them in the G2 phase of the cell cycle. Vpr is conserved among all primate lentiviruses, suggesting an important role in the virus life cycle. Moreover, in this study we show...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Stivahtis, G L, Soares, M A, Vodicka, M A, Hahn, B H, Emerman, M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191649/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9151821/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.6.4331-4338.1997
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