Stereochemical evaluation of the relative activities of the cinchona alkaloids against Plasmodium falciparum.

Quinine and quinidine were over 100 times more active than 9-epiquinine and 9-epiquinidine against chloroquine-sensitive Plasmodium falciparum and over 10 times more active against chloroquine-resistant P. falciparum. Since the only structural difference between quinine, quinidine, 9-epiquinine, and...

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Опубликовано в::	Antimicrob Agents Chemother
Главные авторы:	Karle, J M, Karle, I L, Gerena, L, Milhous, W K
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 1992
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191617/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1510452/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.7.1538
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