2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo.

1. The ability of 2-amino-4-methylpyridine to inhibit the catalytic activity of the inducible NO synthase (NOS II) enzyme was characterized in vitro and in vivo. 2. In vitro, 2-amino-4-methylpyridine inhibited NOS II activity derived from mouse RAW 264.7 cells with an IC50 of 6 nM. Enzyme kinetic st...

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Main Authors: Faraci, W. S., Nagel, A. A., Verdries, K. A., Vincent, L. A., Xu, H., Nichols, L. E., Labasi, J. M., Salter, E. D., Pettipher, E. R.
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1915898/
https://ncbi.nlm.nih.gov/pubmed/8937711
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