GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo

1. GW274150 ([2-[(1-iminoethyl) amino]ethyl]-L-homocysteine) and GW273629 (3-[[2-[(1-iminoethyl)amino]ethyl]sulphonyl]-L-alanine) are potent, time-dependent, highly selective inhibitors of human inducible nitric oxide synthase (iNOS) vs endothelial NOS (eNOS) (>100-fold) or neuronal NOS (nNOS) (&...

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Main Authors: Alderton, Wendy K, Angell, Anthony D R, Craig, Caroline, Dawson, John, Garvey, Edward, Moncada, Salvador, Monkhouse, Jayne, Rees, Daryl, Russell, Linda J, Russell, Rachel J, Schwartz, Sheila, Waslidge, Neil, Knowles, Richard G
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576141/
https://ncbi.nlm.nih.gov/pubmed/15778742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706168
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