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Use of D gene segments with irregular spacers in terminal deoxynucleotidyltransferase (TdT)(+/+) and TdT(−/−) mice carrying a human Ig heavy chain transgenic minilocus

D gene segments with irregular spacers (DIR) are D gene segments that are specific to higher primates. Their use is controversial because of their G+C-rich long sequences. In the human, it has always been tempting to assume that a complementarity-determining region 3 sequence has been added by termi...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Tuaillon, Nadine, Capra, J. Donald
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19158/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9465080/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.4.1703
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