Scrapie infectivity correlates with converting activity, protease resistance, and aggregation of scrapie-associated prion protein in guanidine denaturation studies.

Denaturation studies with guanidine HCl (GdnHCl) were performed to test the relationship between scrapie infectivity and properties of scrapie-associated prion protein (PrP(Sc)). Large GdnHCl-induced reductions in infectivity were associated with the irreversible elimination of both the proteinase K...

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Argitaratua izan da:	J Virol
Egile Nagusiak:	Caughey, B, Raymond, G J, Kocisko, D A, Lansbury, P T
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Microbiology (ASM) 1997
Gaiak:	Research Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191566/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9094691/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.5.4107-4110.1997
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