Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en.

Here we report the isolation of influenza virus A/turkey/Minnesota/833/80 (H4N2) with a mutation at the catalytic residue of the neuraminidase (NA) active site, rendering it resistant to the novel NA inhibitor 4-guanidino-Neu5Ac2en (GG167). The resistance of the mutant stems from replacement of one...

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发表在:	J Virol
Principais autores:	Gubareva, L V, Robinson, M J, Bethell, R C, Webster, R G
格式:	Artigo
语言:	Inglês
出版:	American Society for Microbiology (ASM) 1997
主题:	Research Article
在线阅读:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191482/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9094607/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.5.3385-3390.1997
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