A helper-dependent system for adenovirus vector production helps define a lower limit for efficient DNA packaging.

Adenoviruses (Ads) are intermediate-sized mammalian DNA viruses with a double-stranded linear genome of 36 kb. The icosohedral virion has been shown to accommodate up to 105% of the wild-type genome length, and genomes larger than this size are either unpackageable or extremely unstable, frequently...

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Pubblicato in:	J Virol
Autori principali:	Parks, R J, Graham, F L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191467/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9060698/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.4.3293-3298.1997
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