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Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution

BACKGROUND: Many of the mutations accumulated by naturally evolving proteins are neutral in the sense that they do not significantly alter a protein's ability to perform its primary biological function. However, new protein functions evolve when selection begins to favor other, "promiscuou...

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Détails bibliographiques
Auteurs principaux: Bloom, Jesse D, Romero, Philip A, Lu, Zhongyi, Arnold, Frances H
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1914045/
https://ncbi.nlm.nih.gov/pubmed/17598905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6150-2-17
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