Role of cdk2 in the sequential phosphorylation/activation of C/EBPβ during adipocyte differentiation

Upon induction of differentiation, growth-arrested (G(1) phase) 3T3-L1 preadipocytes express CCAAT/enhancer binding protein-β (C/EBPβ), initiating a transcriptional cascade. C/EBPβ immediately undergoes a priming phosphorylation (on Thr(188)) by MAPK/ERK. However, the acquisition of DNA binding and...

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Hlavní autoři: Li, Xi, Kim, Jae Woo, Grønborg, Mads, Urlaub, Henning, Lane, M. Daniel, Tang, Qi-Qun
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913868/
https://ncbi.nlm.nih.gov/pubmed/17601773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703771104
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