Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity.

Human MxA protein is an interferon-induced 76-kDa GTPase that exhibits antiviral activity against several RNA viruses. Wild-type MxA accumulates in the cytoplasm of cells. TMxA, a modified form of wild-type MxA carrying a foreign nuclear localization signal, accumulates in the cell nucleus. Here we...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Ponten, A, Sick, C, Weeber, M, Haller, O, Kochs, G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191379/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9060610/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.4.2591-2599.1997
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