Construction, replication, and immunogenic properties of a simian immunodeficiency virus expressing interleukin-2.

To study the effect of interleukin-2 (IL-2) on simian immunodeficiency virus (SIV) replication, pathogenesis, and immunogenicity, we replaced the nef gene of SIVmac239 by the IL-2 coding region. The virus, designated SIV-IL2, stably expressed high levels of IL-2 in cell culture. In comparison to SIV...

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Autors principals: Gundlach, B R, Linhart, H, Dittmer, U, Sopper, S, Reiprich, S, Fuchs, D, Fleckenstein, B, Hunsmann, G, Stahl-Hennig, C, Uberla, K
Format: Artigo
Idioma:Inglês
Publicat: 1997
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC191330/
https://ncbi.nlm.nih.gov/pubmed/9032357
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