Construction, replication, and immunogenic properties of a simian immunodeficiency virus expressing interleukin-2.

To study the effect of interleukin-2 (IL-2) on simian immunodeficiency virus (SIV) replication, pathogenesis, and immunogenicity, we replaced the nef gene of SIVmac239 by the IL-2 coding region. The virus, designated SIV-IL2, stably expressed high levels of IL-2 in cell culture. In comparison to SIV...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Gundlach, B R, Linhart, H, Dittmer, U, Sopper, S, Reiprich, S, Fuchs, D, Fleckenstein, B, Hunsmann, G, Stahl-Hennig, C, Uberla, K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191330/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9032357/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.3.2225-2232.1997
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