RNAIII-Inhibiting-Peptide-Loaded Polymethylmethacrylate Prevents In Vivo Staphylococcus aureus Biofilm Formation

Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release...

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Bibliographic Details
Main Authors: Anguita-Alonso, Paloma, Giacometti, Andrea, Cirioni, Oscar, Ghiselli, Roberto, Orlando, Fiorenza, Saba, Vittorio, Scalise, Giorgio, Sevo, Milica, Tuzova, Marina, Patel, Robin, Balaban, Naomi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2007
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913233/
https://ncbi.nlm.nih.gov/pubmed/17116671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00580-06
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