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How Well Can We Understand Large-Scale Protein Motions Using Normal Modes of Elastic Network Models?

In this article, we apply a coarse-grained elastic network model (ENM) to study conformational transitions to address the following questions: How well can a conformational change be predicted by the mode motions? Is there a way to improve the model to gain better results? To answer these questions,...

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Detalhes bibliográficos
Main Authors: Yang, Lei, Song, Guang, Jernigan, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913142/
https://ncbi.nlm.nih.gov/pubmed/17483178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.095927
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