DNA Damage, Homology-Directed Repair, and DNA Methylation

To explore the link between DNA damage and gene silencing, we induced a DNA double-strand break in the genome of Hela or mouse embryonic stem (ES) cells using I-SceI restriction endonuclease. The I-SceI site lies within one copy of two inactivated tandem repeated green fluorescent protein (GFP) gene...

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Bibliographische Detailangaben
Hauptverfasser: Cuozzo, Concetta, Porcellini, Antonio, Angrisano, Tiziana, Morano, Annalisa, Lee, Bongyong, Pardo, Alba Di, Messina, Samantha, Iuliano, Rodolfo, Fusco, Alfredo, Santillo, Maria R, Muller, Mark T, Chiariotti, Lorenzo, Gottesman, Max E, Avvedimento, Enrico V
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2007
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913100/
https://ncbi.nlm.nih.gov/pubmed/17616978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0030110
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