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Realm of PD-(D/E)XK nuclease superfamily revisited: detection of novel families with modified transitive meta profile searches

BACKGROUND: PD-(D/E)XK nucleases constitute a large and highly diverse superfamily of enzymes that display little sequence similarity despite retaining a common core fold and a few critical active site residues. This makes identification of new PD-(D/E)XK nuclease families a challenging task as they...

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Detalhes bibliográficos
Main Authors: Knizewski, Lukasz, Kinch, Lisa N, Grishin, Nick V, Rychlewski, Leszek, Ginalski, Krzysztof
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913061/
https://ncbi.nlm.nih.gov/pubmed/17584917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-7-40
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