Fast repair of O(6)-ethylguanine, but not O(6)-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea

Differential repair of structurally distinct mutagenic lesions in critical genes may influence the cellular risk of malignant conversion. We have investigated rat mammary tumorigenesis induced by N-ethyl-N-nitrosourea (EtNU) versus N-methyl-N-nitrosourea (MeNU) with respect to tumor incidence, ras g...

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Bibliographic Details
Main Authors: Engelbergs, Jörg, Thomale, Jürgen, Galhoff, Anke, Rajewsky, Manfred F.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1998
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC19127/
https://ncbi.nlm.nih.gov/pubmed/9465068
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