Rapamycin stimulates viral protein synthesis and augments the shutoff of host protein synthesis upon picornavirus infection.

The immunosuppressant drug rapamycin blocks progression of the cell cycle at G1 in mammalian cells and yeast. We recently showed that rapamycin inhibits both in vitro and in vivo cap-dependent, but not cap-independent, translation. This inhibition is causally related to reduced phosphorylation and c...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Beretta, L, Svitkin, Y V, Sonenberg, N
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190998/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8971030/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.12.8993-8996.1996
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